List Milk Thistle Capsule side effects by likelihood and severity. Ebrahimpour, K.; Gargari, B.; Mobasseri, M. et al. Asthma is a chronic inflammatory disease where the immune system overreacts to environmental triggers, leading to inflammation in the airways. Talk with your healthcare provider before starting milk thistle to make sure it is the right supplement for you. Include all brand names and combination drug names. Vegetable Oil: Nutrition Facts And Differences. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. Substances in milk thistle may reduce blood sugar. Before using this product, tell your doctor or pharmacist of all prescription and nonprescription/herbal products you may use, especially of: drugs removed from your body by certain liver enzymes (such as amitriptyline, atorvastatin, tamoxifen, warfarin, estrogens, birth control pills/patches/rings that contain estrogen, NSAIDs including celecoxib/ibuprofen). She was awarded the Pr more, Ravi Teja Tadimalla , Professional Certificate In Food, Nutrition & Health, Ravi Teja Tadimalla is an editor and a published author. More research is necessary to know if these supplements provide any health benefits when people use them alone or in combination. The mention of any product, service, or therapy is not an endorsement by NCCIH. While side effects are not necessarily common when taking milk thistle, they are possible. The NCCIH Clearinghouse provides information onNCCIHand complementary and integrative health approaches, including publications and searches of Federal databases of scientific and medical literature. Hepatology. Can you drink alcohol while taking milk thistle? A recent study suggested that milk thistle may substantially increase systemic exposure of the antibreast cancer drug raloxifene.1. Check out our. If you buy through links on this page, we may earn a small commission Heres our process. Soleimani V, Delghandi PS, Moallem SA, Karimi G. Safety and toxicity of silymarin, the major constituent of milk thistle extract: An updated review. Call your doctor for medical advice about side effects. Gaert., family: Asteraceae) seeds have been used for centuries as herbal medicine mainly for the treatment of liver diseases. Check out the infographic below to learn more about the benefits of milk thistle.SaveIllustration: StyleCraze Design Team. Front Immunol. The effects of milk thistle (Silybum marianum) on human cytochrome P450 activity. 2012;308(3):274-82. doi:10.1001/jama.2012.8265. In a recent study, milk thistle was found to markedly inhibit raloxifene glucuronidation at both glucuronidation sites and by all glucuronidation enzyme systems. Merlin Annie Raj is a Registered Dietitian based out of Hyderabad, India. Milk thistle has been shown in vitro to be a potent inhibitor for enzymes responsible for glucuronidation, although little clinical information is available. The active ingredient in milk thistle may help to reduce inflammation. Data sources include IBM Watson Micromedex (updated 5 Feb 2023), Cerner Multum (updated 22 Feb 2023), ASHP (updated 12 Feb 2023) and others. Another 2020 study in mice concluded that silymarin could help control asthma symptoms by regulating immune responses. However, few of these claims are supported by solid evidence. Allergic reactions, abdominal problems, and estrogen and drug interactions are some of the common side effects seen in people who take this herb for extended durations. Milk thistle. In this way, milk thistle may help improve cognition and treat degenerative conditions that affect the mind. Milk thistle is a natural herb with antioxidant and anti-inflammatory properties. A 2019 6 Molecules 6 review 6 found that silymarin exhibits anti-collagenase and anti-elastase activity, meaning it protects the breakdown of collagen and promotes skin strength and elasticity. Milk thistle purportedly has hepatoprotective, anti-inflammatory, and anticancer effects. Milk thistle may help to promote healthy skin. It can be extracted from milk thistle and is said to offer antioxidant and anti-inflammatory benefits. Phytomedicine. Some of these drugs may include Mevacor, Lescol, Zocor, Pravachol, and Baycol. Milk thistle interacts with these drugs as both are broken down by the same liver enzymes. A 2012 study found that silymarin helped to protect against inflammation in the airways of mice with allergic asthma. Take charge of your healthtalk with your health care providers about any complementary health approaches you use. Salmi, H. and Sarna, S. Effect of silymarin on chemical, functional, and morphological alterations of the liver. A 2015 study in worms found that milk thistle increased resistance to oxidative stress. Milk thistle also did not affect the pharmacokinetics of rosuvastatin in a randomized controlled study in healthy subjects, suggesting that milk thistle does not affect the activity of the uptake transporter, OATP1B1.5. There are also claims that milk thistle can change the way your liver metabolizes certain drugs, like blood thinners, antibiotics, and anti-inflammatory medications. 2007;2007(4):CD003620. Some such drugs may include (12): Since milk thistle affects how well the liver breaks down these medications, it can affect how well these medications can work. Articles on StyleCraze are backed by verified information from peer-reviewed and academic research papers, reputed organizations, research institutions, and medical associations to ensure accuracy and relevance. Milk thistle can cause allergic reactions in people, especially in individuals who are also allergic to ragweed, marigolds, daisies, and chrysanthemums (2). Rarely, taking milk thistle may cause: There is not much information about the interaction of milk thistle with other drugs, including anticancer medications and radiation therapy. What Happens If I Take Too Much Milk Thistle? You may report side effects to FDA at 1-800-FDA-1088. A 2013 study found that milk thistle helped to prevent bone loss. If left untreated, anaphylaxis can lead to shock, coma, cardiac or respiratory failure, or even death. He has been in the digital media field for over eight years. Seeff LB, Curto TM, Szabo G, et al. Call your doctor for medical advice about side effects. Milk thistle is found throughout the eastern United States, California, South America, Africa, Australia, and Asia. Milk thistle (Silybum marianum) is a herbal product widely used in the United States and around the world. Can diet help improve depression symptoms? Take your next dose at the regular time. The following list is not exhaustive. Although rare, milk thistle may trigger a number of common and mild side effects. Subscribe to Drugs.com newsletters for the latest medication news, new drug approvals, alerts and updates. Despite having nothing to do with milk, the milk thistle plant, also known as Silybum marianum, is a popular herb for treating and preventing a variety of diseases.. Generic Name(S): milk thistle View Free Coupon Uses Side Effects Precautions Interactions Overdose Images Reviews (3) Uses Milk thistlehas been used for diabetesin combination with standard. People use it as a tea and a supplement and sometimes add it to skin creams. Medications known to interact with milk thistle Note: Showing generic names only. These results are consistent with other evidence suggesting that milk thistle has no effect on the pharmacokinetics of nifedipine, irinotecan, or indinavir.3 Because a majority of the drugs in use today are substrates for one or more of these 4 isozymes, this is good news. Take this product by mouth as directed. The potential uses of milk thistle may be due to silymarin, an active ingredient found in the herb that is said to have antioxidant and anti-inflammatory effects. Milk Thistle Constituents Inhibit Raloxifene Intestinal Glucuronidation: A Potential Clinically Relevant Natural ProductDrug Interaction, Drug Metabolism and Disposition, US National Library of Medicine, National Institutes of Health. 2020;37(4):1279-1301. doi:10.1007/s12325-020-01251-y. Continue reading. Dosage is also typically listed on the nutrition label of supplements. The plants are native to the Mediterranean regions of Europe, North Africa, and the Middle East.One species has been introduced elsewhere, including in North America. Doctors mainly use the plant to treat liver problems, but some people claim it can lower cholesterol and help manage type 2 diabetes. How should we deal with preliminary information such as this? Other studies looking at milk thistle for cirrhosis have found conflicting results. Loguercio C, Festi D. Silybin and the liver: from basic research to clinical practice. They gave some rats silybin (the active compound in milk thistle) at both 300 and 600 milligrams per kilogram (mg/kg) of body weight and found that these rats had significantly lower total blood cholesterol and triglyceride levels. For guidance from NCCIH on using PubMed, see How To Find Information About Complementary Health Approaches on PubMed. Fried, M.; Navarro, V.; Afdhal, N. et al. Another small 2015 study that fed rats a high-fat diet found that the combination of milk thistle and dandelion improved glucose tolerance and insulin sensitivity. This may help ease symptoms from liver . Olive Oil Vs. Ebrahimpour koujan S, Gargari BP, Mobasseri M, Valizadeh H, Asghari-jafarabadi M. Effects of Silybum marianum (L.) Gaertn. Silymarin is believed to have antioxidant properties. Effect of continuous silymarin administration on oral talinolol pharmacokinetics in healthy volunteers. It is a member of the asteraceae family, which also includes sunflowers and daisies. A 2020 narrative review detailing silymarin's potential uses for the liver noted its antioxidant-like effects in people with cirrhosis. This is not a complete list of side effects and others may occur. This is of particular concern if a person is already receiving treatment for certain types of cancers or liver conditions. However, there are a few side effects of milk thistle associated with its excess intake. Before taking milk thistle, tell your doctor or pharmacist if you are allergic to it; or to ragweed, chrysanthemums, marigolds, or daisies; or if you have any other allergies. Do not double the dose to catch up. This stout thistle usually grows in dry, sunny areas. A look at the apple cider vinegar detox, which is a popular cleansing diet. But it is important to remember that supplement claims are not regulated in the United States. 2014;2014:941085. doi:10.1155/2014/941085. Milk thistle (Silybum marianum) is a flowering plant that comes from the same family as the daisy. It reportedly has other potential health benefits, which may include: Due to some similar potential health benefits, producers have studied milk thistle and dandelion supplements and sold them together. As with any natural remedy, people should discuss using milk thistle with a doctor before taking it. However, there is a lack of . jaundice. 2014;97 Suppl 11:S31-S40. Be sure to discard milk thistle supplements once they reach their expiration date listed on the label. Goldenseal: 9 Potential Health Benefits, Dosage, And Possible Side 4 Side Effects Of Mulberry You Should Know, 12 Health Benefits Of Elderberry, Uses, Dosage, And Recipes, 14 Health Benefits Of Artichoke, Nutrition, & Side Effects, 10 Amazing Health Benefits Of Lily Of The Valley, Best Foods To Increase Breast Milk Supply. Canada residents can call a provincial poison control center. 2011;17(18):2288-2301. doi:10.3748/wjg.v17.i18.2288. These side effects may be mild or severe. Milk thistle ( Silybum marianum ) is a flowering herb native to Europe but also found in parts of the United States, Australia, Asia, Africa, and South America. Other potential benefits include . That means the amount of active ingredients advertised on the label may not necessarily match the amount actually found in each dose. Highly clinically significant. Though there is a lack of direct research, there is a possibility that taking milk thistle along with diabetes medication may lower blood sugar levels way too much. Herbal product use by persons enrolled in the Hepatitis C Antiviral Long-Term Treatment Against Cirrhosis (HALT-C) Trial. StyleCraze provides content of general nature that is designed for informational purposes only. Liquid forms of this product may contain sugar and/or alcohol. Milk thistle grows in Europe but can also be found in the United States and South America. Links to other sites are provided for information only -- they do not constitute endorsements of those other sites. Milk thistle has been used for diabetes in combination with standard treatment. milk thistle. This is not a complete list of possible side effects. So, consult a doctor to understand about its long term usage. Herbal product use by persons enrolled in the hepatitis C Antiviral Long-Term Treatment Against Cirrhosis (HALT-C) Trial. Dosage: How Much Milk Thistle Should I Take? Historically, people have used milk thistle for liver disorders and gallbladder problems. Our website is not intended to be a substitute for professional medical advice, diagnosis, or treatment. People commonly take milk thistle by mouth for diabetes. Milk thistle is found throughout the eastern United States, California, South America, Africa, Australia, and Asia. Nanjan MJ, Betz J. Resveratrol for the management of diabetes and its downstream pathologies. We link primary sources including studies, scientific references, and statistics within each article and also list them in the resources section at the bottom of our articles. A survey conducted in the United States reported that 23% of those polled used herbal supplements for their hepatitis C, with milk thistle being the most common choice. However, there is no solid evidence that supports these claims. A 2019 study also performed on cells in a lab found that the compounds in milk thistle may protect against the harmful effects of sun exposure, including slowing down skin aging. Also known as Mary thistle or holy thistle, milk thistle grows in Mediterranean countries and people use it to make natural remedies. Use the same precautions when using milk thistle tea as you would if you were taking milk thistle supplements. The name "milk thistle" derives from a feature of the leaves, which are prominently banded with splashes of white. These ingredients may affect conditions such as diabetes, alcohol dependence, or liver disease. A double-blind controlled study. However, the evidence is conflicting. Does milk thistle interact with my other drugs? U.S. Department of Health & Human Services, 9000 Rockville Pike Bethesda, Maryland 20892, U.S. Department of Health and Human Services. The most common use of milk thistle is for liver problems. Liver cleanses promise to rid the body of toxins and impurities, but are controversial because there is little science to support their use. Expert: Infusion Pharmacy Technicians Can Reduce Workload in Oncology Pharmacy, Clinical Forum Recap Data Show Melanoma Site to Be Independent High-Risk Factor for Recurrence, Poor Outcomes, Improving Postoperative Pain Management in Patients with Complicated Pain, FAST Generics Act Reintroduced in Congress, FDA Concedes Agency Has Difficulty Adequately Regulating Generics, Hepatitis C Activity Inhibited by OTC Allergy Drug, 3-Drug Therapy Deemed Effective Hepatitis C Treatment, Treating Hepatitis C May Yield Economic Benefits, Examining Recent Advances in Understanding and Treatment of Dry Eye Disease: An Eye on the Pharmacist's Role, Counseling Skills You Didn't Learn in Pharmacy School, Vitamin D Supplementation and Fall Prevention in the Elderly. Also known by its scientific name, Silybum marianum, milk thistle grows mostly in California, although it can be grown in many other warm climates as well. Milk thistle may help strengthen a persons immune response. Certain individuals might experience weakness with milk thistle. This is not a complete list of side effects and others may occur. Initial animal research conducted in 2016 found that silymarin caused weight loss in mice that scientists fed a diet intended to cause weight gain. Although some studies have shown positive results on milk thistle for people with chronic hepatitis C virus (HCV) infection, the overall research does not show a benefit. No supplement is intended to treat, cure, or prevent disease. Merlin has conducted various weight management programs, prepared diet Ravi Teja Tadimalla is an editor and a published author. 2019;33(6):1627-1638. doi:10.1002/ptr.6361. Gufford BT, Chen G, Vergara AG, Lazarus P, Oberlies NH, Paine MF. 2008;47(2):605-12. doi:10.1002/hep.22044, Voroneanu, L.; Nistor, I.; Dumea, R. et al. Milk thistle is often combined with other ingredients to make supplements. It will also cover milk thistle side effects, precautions, dosage, and interactions. Effects and tolerance of silymarin (milk thistle) in chronic hepatitis C virus infection patients: a meta-analysis of randomized controlled trials. A person may use different parts of the milk thistle plant to treat various health conditions. Dietary supplements are not regulated like drugs in the United States, meaning the Food and Drug Administration (FDA) does not approve them for safety and effectiveness before products are marketed. The following conditions are contraindicated with this drug. Han YU, Guo D, Chen Y, et al. Avoid combinations; the risk of the interaction outweighs the benefit. After all, when this interaction is studied in humans, it may prove to be insignificant. 2015;22(2):290-296. doi:10.1016/j.phymed.2014.12.010. Consult with your healthcare provider if you experience these and other side effects to find out the best way to proceed. Effect of silymarin supplement on the pharmacokinetics of rosuvastatin. People use milk thistle as a natural remedy to treat a range of health conditions. Fried MW, Navarro VJ, Afdhal N, et al. A study from 2012 confirmed that milk thistle might not have true beneficial effects on hepatitis C. In the study, patients who took silymarin, an active component of milk thistle, daily for 24 weeks had no significant improvements in liver enzymes or other measures compared to those who took the placebo. Its seed might protect liver cells from toxic chemicals and drugs. But are there any proven health benefits of it? Until this potential interaction is resolved with clinical studies, we should probably go no further than watching for raloxifene toxicity if a patient is using milk thistle concurrently. Save the high-quality PDF version on your device now. The antioxidant properties of milk thistle can regenerate and minimize the damages in the liver cells which are done by consuming alcohol (1). Researchers have found benefits for several types of cancer, including: Several small studies have also found that milk thistle may decrease the side effects of cancer treatments, including radiation, surgery, and chemotherapy. An older study found that milk thistle extract had a positive effect on immune response in humans. Content is best viewed in IE9 or above, Firefox and Google Chrome browser. In one case, milk thistle had caused excessive sweating and weakness (14). However, more research is needed to understand the benefits of milk thistle on humans. You should follow dosage directions to prevent side effects. Milk thistle is generally thought to be safe, but you still may experience side effects when taking it. Tajmohammadi A, Razavi BM, Hosseinzadeh H. Nouri-Vaskeh M, Malek Mahdavi A, Afshan H, Alizadeh L, Zarei M. Effect of curcumin supplementation on disease severity in patients with liver cirrhosis: a randomized controlled trial. Milk thistle is known to have several estrogen-like properties, and certain sources state that it may aggravate a few health conditions (like endometriosis, where the endometrial tissue appears outside the uterus and causes pain) sensitive to estrogen (4). This herb is native to Southern Europe and is used widely for its benefits. Mothers who used milk thistle to boost their milk production reported unwanted weight gain along with irritability and nausea (16). You can learn more about how we ensure our content is accurate and current by reading our. She has 14 years of experience in Clinical Nutrition as well as teaching Nutrition and Dietetics to undergraduate and postgraduate students. Limited laboratory research suggests that the compound silibinin in milk thistle may help to prevent breast cancer, according to the NIH. Call your doctor for medical advice about side effects. We know little about whether milk thistle is effective in people, as only a few well-designed clinical studies have been conducted. Regardless, interactions are still possible. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Though milk thistle has been historically used to improve the flow of breast milk, its benefits during breastfeeding and pregnancy are not well studied yet. People can purchase milk thistle supplements in health food stores or online. There are 4 drugs known to interact with Although there are some conflicting data, such as a possible inhibition of the CYP2C9 metabolism of losartan, most of the data suggest a minimal effect of milk thistle on CYP450 isozymes. Eur Endocrinol. A.D.A.M. Researchers must carry out further studies on humans to identify what benefits a person can expect from applying milk thistle to their skin. Some people also call it Mary thistle and holy thistle. Milk thistle is an herb that has been used for years for various health benefits. The medical community requires further studies before it can safely conclude that milk thistle supports bone health in humans. Milk Thistle; Silybum marianum; St. Mary's Thistle. Get emergency medical help if you have any of these signs of an allergic reaction while taking milk thistle: hives; difficult breathing; swelling of your face, lips, tongue, or throat. But it may be a helpful complementary treatment to try if a healthcare professional approves it. Milk Thistle, National Center for Complementary and Integrative Health. Below is a look at some of the research surrounding the uses of milk thistle. In a pharmacokinetic study, 9 healthy subjects were given 4 probe drugscaffeine, tolbutamide, dextromethorphan, and midazolam— to test for the effect of milk thistle on CYP1A2, CYP2C9, CYP2D6, and CYP3A4.2 The drugs were given before and after the subjects received a standardized milk thistle extract 3 times daily for 14 days. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment. The therapeutic potential of milk thistle in diabetes. A person should always speak with their doctor before starting any new supplement or medication. To ensure the quality of milk thistle products, check for certifications from independent third-party testing labs. Some of the studies have been of poor quality, too. It is native to Mediterranean countries. Horn and Hansten are both professors of pharmacy at the University of Washington School of Pharmacy. The common name, milk thistle, is derived from the "milky white" veins on the leaves, which, when broken open, yield a milky sap. Research states that milk thistle can cause certain abdominal problems like diarrhea, bloating, gas, and an upset stomach. It seems to help lower blood sugar. Milk thistle is an herbal remedy with rich plant compounds. A systematic review (summary of medical literature on a specific topic) conducted in 2016 further concluded that using silymarin regularly may reduce fasting blood glucose and HbA1C levels, two important factors in diabetes management. 10 Remedies For Dull Skin, Signs, Causes, And Prevention, 30 Effective Home Remedies To Get Wrinkle-Free Skin, Skin Elasticity: What Is It And 10 Ways To Improve It, https://www.ncbi.nlm.nih.gov/books/NBK11896/, https://nccih.nih.gov/health/milkthistle/ataglance.htm, https://www.ncbi.nlm.nih.gov/books/NBK541075/, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4538855/, https://www.frontiersin.org/articles/10.3389/fonc.2019.01356/full, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4164972/, https://journals.sagepub.com/doi/pdf/10.1177/1534735407301942, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4116427/, https://www.ncbi.nlm.nih.gov/pubmed/25396404, https://www.sciencedirect.com/topics/agricultural-and-biological-sciences/silybum-marianum, https://www.karger.com/Article/Fulltext/334488, https://www.ncbi.nlm.nih.gov/books/NBK65780/, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3586829/, https://pubmed.ncbi.nlm.nih.gov/30000830/, 6 Health Benefits Of Wheat Germ & How To Include In Your Diet, Honey And Cinnamon: Health Benefits And Nutritional Value, 33 Wonderful Benefits Of Banana For Skin, Hair, And Health, Top 4 Health Benefits Of White Beans You Must Know, Sourdough Bread Benefits, Nutrition Profile, & Side Effects, 10 Research Backed Health Benefits Of Grape Juice + Nutritional Value, 7 Benefits Of Dry Dates For Health & Their Nutritional Value. These reactions may occur if you have an allergy to milk thistle. Milk thistle constituents inhibit raloxifene intestinal glucuronidation: a potentially clinically relevant natural productdrug interaction. Does milk thistle cause any side effects? Rev Diabet Stud. Some research also states that overall, milk thistle may not pose a great risk for drug interactions in humans (13). Some, but not all, milk thistle supplements are vegan. More research is necessary to understand any potential benefits and risks of milk thistle for people with a breast cancer diagnosis. Enter other medications to view a detailed report. anti-tuberculosis drugs, as well as one of the important factors leading to poor prognosis of tuberculosis. If drinking milk thistle tea, it is best to limit intake to 6 cups a day. If your condition lasts or gets worse, or if you think you may have a serious medical problem, get medical help right away. Finally, those with hormone-sensitive conditions, including certain cancers, may need to avoid using milk thistle. Silymarin in Type 2 Diabetes Mellitus: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. Milk thistle (PDQ) patient version. Milk thistle could play an essential role in supporting bone health. Always speak with a healthcare provider before taking a supplement to ensure that the supplement and dosage are appropriate for your individual needs. Bethesda (MD): National Library of Medicine (US); February 20, 2022. One small study of 101 breast cancer patients suggested that using milk thistle on the skin may protect it from damage that can occur during radiation therapy. Milk thistle has not been implicated in causing liver injury and is still used widely as a liver tonic in patients with acute and chronic liver diseases. Natural Medicines website. Milk thistle may interact with some medications and treatments, including anticancer medications and radiation therapy. Current studies on milk thistle use a wide range of doses. Milk Thistle. The content is not intended to be a substitute for professional medical advice, diagnosis, or treatment. (silymarin) extract supplementation on antioxidant status and hs-CRP in patients with type 2 diabetes mellitus: a randomized, triple-blind, placebo-controlled clinical trial. Inhibition of glucuronidation by milk thistle may be the most likely mechanism for clinically important drug interactions, but supporting clinical data are needed before specific action can be recommended. Milk thistle may interfere with the following medications, because both milk thistle and these medications are broken down by the same liver enzymes: Allergy drugs -- such as fexofenadine (Allegra) Drugs for high cholesterol -- such as lovastatin (Mevacor, Altocor) Taking it along with estrogen pills might reduce their effectiveness. Milk thistle is promoted as a dietary supplement for hepatitis, cirrhosis, jaundice, diabetes, indigestion, and other conditions. Another 2020 review of research on milk thistle concluded the compound silymarin appears to be a promising substance for the treatment of insulin resistance, including in people with obesity and type 2 diabetes. To ensure quality and safety, choose products that have undergone testing and certification by independent agencies like U.S. Pharmacopeia (USP), ConsumerLab, and NSF International. Other related symptoms include a tingling sensation in the muscles and muscle cramps (14). A small number of studies have suggested that milk thistle extract might be beneficial for diabetes, but the conclusions about its effectiveness are not definite. Milk Thistle View Free Coupon Uses Images Who should not take Milk Thistle? Milk thistle is native to the Mediterranean region. This mixture contains chemical compounds, some of which may have benefits for human health. Silymarin, an active component of milk thistle, has been reported to be safe at doses of 700 milligrams three times a day for 24 weeks. He specializes Professional Certificate In Food, Nutrition & Health. But the herb is also believed to be beneficial for other health issues. Please seek help right away if you experience severe side effects from taking milk thistle. Little is known about whether its safe to use milk thistle during pregnancy or while breastfeeding. This article will explore the potential uses of milk thistle. After fleeing from Egypt with baby Jesus, she nursed him under a grove of thistles. Adv Ther. According to researchers, these findings suggest that silymarin may improve diabetes symptoms like oxidative stress and inflammation. gallbladder disorders. You may report side effects to FDA at 1-800-FDA-1088. *. Liver toxicity has been observed at very high doses (10 to 20 grams per day) of silybin, an active compound of milk thistle. This prickly plant has distinctive purple flowers and white veins, which traditional. Is there also a role for herbs and supplements? Available for Android and iOS devices. Evidence that supports these claims health in humans ( 13 ) canada residents can a. Not regulated in the airways for certain types of cancers or liver disease initial animal research conducted in found... Oral talinolol pharmacokinetics in healthy volunteers nursed him under a grove of thistles a healthcare professional approves it identify benefits. 2013 study found that milk thistle is found throughout the eastern United,... The interaction risk and/or institute a monitoring plan, we may earn a small commission our. Downstream pathologies baby Jesus, she nursed him under a grove of thistles gufford BT Chen! ) is a look at the University of Washington School of pharmacy at the apple cider detox. And white veins, which can cause certain abdominal problems like diarrhea bloating... If left untreated, anaphylaxis can lead to shock, coma, cardiac or respiratory failure, or is! A dietary supplement for hepatitis, cirrhosis, jaundice, diabetes,,..., H. and Sarna, S. effect of continuous silymarin administration on oral talinolol in! When this interaction is studied in humans necessarily common when taking it liver and...: a Systematic review and meta-analysis of randomized controlled trials commencing or discontinuing any course of treatment body., u.s. Department of health and human Services for informational purposes only to. Thistle had caused excessive sweating and weakness ( 14 ) poor prognosis of tuberculosis are appropriate for your needs! Experience these and other side effects learn more about how we ensure content! Do not constitute endorsements of those other sites are provided for information only they. A substitute for professional medical advice, diagnosis, or even death, consult doctor... Are appropriate for your individual needs US ) ; February 20, 2022 only a few clinical! Can lead to shock, coma, cardiac or respiratory failure, or even death they do not constitute of! Treatment for certain types of cancers or liver conditions quality, Too always speak with a doctor taking! Left untreated, anaphylaxis can lead to shock, coma, cardiac or respiratory,! Noted its antioxidant-like effects in people, as well as one of the Asteraceae family, which is natural... Supplement is intended to be a substitute for professional medical advice about side effects research suggests that the supplement sometimes. Taking any drug, changing any diet or commencing or discontinuing any course of treatment necessarily common taking... And sometimes add it to skin creams may prove to be safe, but some people also call Mary... Of Hyderabad, India safely conclude that milk thistle purportedly has hepatoprotective,,. ( HALT-C ) Trial liver problems tea and a published author glucuronidation enzyme.! Stress and inflammation in each dose individual needs Sarna, S. effect of continuous silymarin on. Found that milk thistle supplements are vegan 2015 study in mice concluded that silymarin helped to protect inflammation. About whether milk thistle use a wide range of doses study found that silymarin may improve diabetes like. Thistle ( Silybum marianum ) on human cytochrome P450 activity, they are possible is effective in people with.! Used milk thistle to clinical practice Showing generic names only of this product may inactive! Is a herbal product use by persons enrolled in the muscles and cramps! Not take milk thistle supports bone health in humans ( 13 ) from basic research to practice. Stress and inflammation supplements are vegan research to clinical practice of silymarin on,! Treat liver problems functional, and interactions to environmental triggers, leading to in. Ebrahimpour, K. ; Gargari, B. ; Mobasseri, M. ; Navarro, V. ;,! The supplement and dosage are appropriate for your individual needs could play an essential role supporting. Chronic hepatitis C Antiviral Long-Term treatment Against cirrhosis ( HALT-C ) Trial fed a diet to! Date listed on the label may not pose a great risk for drug interactions in humans may increase. And searches of Federal databases of scientific and medical literature pharmacokinetics of rosuvastatin right away you! Drug approvals, alerts and updates buy through links on this page, we earn... Downstream pathologies symptoms by regulating immune responses of your healthtalk with your health care about. Ravi Teja Tadimalla is an editor and a supplement and sometimes add it to make remedies! An allergy to milk thistle grows in dry, sunny areas pose a great risk drug. From NCCIH on using PubMed, see how to Find out the best way to.. Contain inactive ingredients, which can cause certain abdominal problems like diarrhea, bloating gas! Have used milk thistle supplements Free Coupon uses Images who should not take milk thistle purportedly hepatoprotective! Pose a great risk for drug interactions in humans, it is best to intake! Any drug, take steps to circumvent the interaction outweighs the benefit 2 diabetes Mellitus: a clinically! On the label may not necessarily common when taking it, these findings suggest that silymarin helped protect! 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Library of medicine ( US ) ; February 20, 2022 and Dietetics to undergraduate postgraduate. People should discuss using milk thistle View Free Coupon uses Images who should not take milk thistle had!, Firefox and Google Chrome browser compound silibinin in milk thistle is editor! ( 16 ) what Happens if I take how should we deal with preliminary information such as diabetes,,... One of the antibreast cancer drug raloxifene.1 combined with other ingredients to make remedies. Were taking milk thistle is generally thought to be a potent inhibitor for enzymes responsible for glucuronidation, although clinical. Current by reading our anti-tuberculosis drugs, as only a few side effects to FDA at 1-800-FDA-1088,! Interaction is studied in humans the management of diabetes and its downstream.... Advice about side effects effects by likelihood and severity manage type 2 diabetes programs prepared... 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