And ever since being off it, I dont feel it hardly anymore Postmenopausal women, who are no longer producing adequate estrogen, will benefit from such an estrogen-like effect, but increased ER activity in young women, who are already producing plenty of estrogen, could result in over-expression of an oncogene (cancer-promoting gene) called ERBB2. have soya yogurts [ Ive suffered from 1/2 hourly hot flushes for 5 years]. Neither of the two forms discussed next are safe. I want to keep my bone safe and at the moment I am having a swollen leg on my left. ), Thank you for sharing your extensive knowledge about bone health and for this venue where questions can be asked! . But, once again, I have no idea of the amount of additional calcium that is entering my body. I have a green smoothie at least 5 days a week with collards or kale. You want to do exercises that strengthen the muscles running up your back along both sides of your spine these are called the multifidi and erector spinae. Strontium is eliminated by our kidneys, so it may accumulate in patients with chronic kidney disease, as their kidneys ability to filter the blood is compromised. Also, breakfast time seems to be the meal which is most easily controlled for Calcium intake and, therefore Strontium is taken at this time. How long is it safe to use at the full recommended dosage and at what dosage is it safe to use after reaching the normal levels? Sorry for the continuing confusion, but I now have the definitive information to answer your questions. As I explained, calcium and strontium compete for absorption, and calcium will always be preferentially absorbed. Other women have written me that they find it easier to take their strontium at night, right before bed, so several hours after they have eaten dinner. AlgaeCal reduced oxidative stress in human osteoblasts by 4-fold compared to controls (untreated cells), 2-fold compared to calcium carbonate, and 2.5-fold compared to calcium citrate. 5.0 out of 5 stars Bone Health. Of the ten volunteers, nine had osteopenia and/or osteoporosis. Regardless, I still think you are correct in suggesting a lower than 680 mg/day dose of strontium citrate may be helpful. I will be looking for it as this would be a very useful test for those of us taking strontium. The decline in DHEA, which is produced by our adrenals & thus not related to menopause at all, can start as early as the late 20s, and research has proven that our levels of DHEA correlate with BMD in both pre- and postmenopausal women. Within 3 hours, you will have digested the yogurt and absorbed the calcium in it. It has been suggested that bone resorption is most active at night, so taking strontium citrate just before bed may result in strontium exerting more of its antiresorptive effects when they are needed most. AlgaeCal Plus provides 1,600 iu of D3 daily, but some of us need more depending upon where we live (latitude impacts our ability to produce vitamin D from sun exposure) and our genetic inheritance, which can greatly affect our ability to maintain healthy levels of vitamin D, which, for 25(OH)D, should be in the range of 50-80 ng/mL. Medicines are intended to help us live longer and healthier, but taking medicines the wrong way or mixing certain drugs and supplements can be dangerous. Thank you so much for all the information and support you have given us! I hope my full review of strontium will put to rest any concerns you might have regarding the potential for any adverse effects from the natural form of strontium, strontium citrate, which is what is present in Strontium Boost. 2 versions of AlgaeCal supplements were used AlgaeCal 1 and AlgaeCal 2. There are many reasons to do so in addition to just being able to take your Strontium Boost unfriendly critters in the digestive tract promote inflammation and interfere with nutrient absorption, and both of those promote bone loss. Strontium ranelate slows down the cells that break down bone. Final ThoughtsWhy Take AHCC On An Empty Stomach? Total Magnesium 300mg. His phone number is 480-767-7119. I did not put flaxseed or chia on my chart in Your Bones b/c these are not as commonly eaten, but I obviously should have done so! I must be honest with you, I have done a lot of research with strontium and when I read Lis thesis paper I was surprised that he was suggesting 170 mg to be more effective. The amounts of the other forms of vitamin K (K1 and MK-4) are so tiny, they will have little impact on activation of Gla-proteins. Again, however, what you (and each of us) is concerned about is YOUR personal potential for adverse effect. Prior to using AlgaeCal, I had been rebuilding bone, but SLOWLY. Vitamin K2 (MK-7) at a dose of 120 mcg/day or even 240 mcg/day is extremely safe. Hi Connie, I am Canadian and the BMD test shows lumbar spine T-score of -2.8 and Femoral neck T-score of 1.8 I took Calcitonin Nasal spray for two years and apparently my bone loss has continuednow I have stopped Calcitonin altogether and I am looking for something else. Your multiple (250 mg) plus AlgaeCal (720 mg) delivers 970 mg. I ordered the AlgeaCal plus and the Strontium can I just take the calcium without the other and still see results with diet and exercise (elliptical 3 xs a week , kettlebell 3 xs a week and yoga 2 xs per week? You may be surprised to see how much calcium your diet is providing when you add it up. And truly, isnt this wonderful? Here are links to these #AskLara: https://www.facebook.com/lara.pizzorno.5/videos/10220814548543995/ If so, discuss alternatives with your physician. So the range of overestimation here is 6.3% to 11.2% of the % of improvement in BMD. I read the article by Meunier that he cited, but it was evident that said article supported 680 mg not 170 mg to be the most effective. For optimal absorption, take on an empty stomach and at least two hours apart from calcium, magnesium or antacids. I hope this answers your question and again, am delighted to hear your bones are in excellent health! LIPUS stimulation on metastatic bone tumors induces differentiation of osteoblasts without proliferation of tumor cells. But let me reiterate, I am NOT paid to be a sales person for AlgaeCal. I started out taking just 1 capsule not because I wanted to take less than 680 mg of strontium but b/c I did not carefully read the label. While the human skeleton is composed of approximately 80% cortical and 20% trabecular bone, it has been observed that Sr absorption is different between these two types of bone, with trabecular bone showing a higher Sr concentration than cortical bone, likely due to the fact that cortical bone has a slower turnover rate compared to trabecular bone. The only red flag I received was for Strontium. Even 1 capsule per day is going to be doing some good for your bones. This made me go back through all the articles and recheck them more punctiliously; I also did some stoichiometry based on the molar masses of strontium and the various anions to see if the discrepancy could be reconciled by various methods used to report dosage (i.e. Hi Carol, Can I take AlgaeCal & Strontium Boost ? Strontium has a chemical similarity to calcium and will replace calcium as the mineral in bone. Postmenopausal womens ovaries no longer produce estrogen, but small amounts of estrogen continue to be produced in many other parts of the body, and these small amounts of estrogen are essential for maintaining bone health. Please ask your doctor to check your thyroid hormone levels (T4, T3, rT3), and if you are hypothyroid, your levels of iodine and selenium should be evaluated. Of course, the elemental vs. compound difference can explain the seeming dosage discrepancy. Still, the optimal situation would have been to direct the women to take their strontium at a time of day several hours before or after consuming calcium-rich foods since this would have improved strontiums absorption. Dialysis is a way of carrying out this process. Hope this answers your question, Lara, What is a suitable no calcium snack to have with the Strontium Citrate? As emphasized in Annual Reports in Medicinal Chemistry, The beneficial effects of the drug [strontium ranelate] on bone metabolism are dependent on the pharmacokinetics of strontium, not ranelic acid. Annual Reports in Medicinal Chemistry, volume 40, 2005, ed. With exercise, this is reducing the overweight problem and settling a diabetic tendency by assisting metformin; blood sugar is very well in control. If you have chronic kidney disease, you should not risk taking strontium. You have given some tips how much of dosage we have to take. Laboratoire dHistodynamique Osseuse, Facult de Mdecine R. Laennec, 69372, Lyon Cedex 08, France. Ive written up all this research for inclusion in the 2nd edition of my book, Your Bones, which will be out in March 2013 its very interesting! Hope this helps, Lara. Hello again Lara: Sources. A total of 48 drugs were selected for oral bioavailability comparison. With the use of AP,SB, women are gaining 1.04% BMD on average (i.e., some even more, some a bit less) when they should have been losing 1-2%. PMID: 24434614 Re #2, following are the citations of a few of these papers (all are available on PubMed) with my italics added for emphasis and my comments on the relevant text: I want to build bone but am apprehensive about replacing calcium with strontium. I looked but could find no other study that has replicated these findings or reported similar findings since. Are you currently taking supplemental strontium? After reading some comments about citrates, some years ago I too Calcium Citrate and ended up with awful heart palpitations and thumping (the only way I know to describe it). Let me know how you do. Strontium is the only mineral in our bones that both lowers the rate of bone resorption and increases the rate at which bone is rebuilt. So interesting! I will do my best to help you. The cross-talk between osteoclasts and osteoblasts in response to strontium treatment: involvement of osteoprotegerin. Lara: One study is 2004 and one is 2012 and rely on use of the ranelate version of strontium not citrate. (2) The first study cited by Genuis et al. (I realize you have read these papers, but wanted to include a couple of quotes from them for others who may be interested and have not.) Please clarify. http://www.lmreview.com/articles/view/Vitamin-K2-Essential-for-Prevention-of-Age-Associated-Chronic-Disease/ May I ask what sort of foods you eat so that they dont compete with the strontium? It doesnt. The information on the strontium/thyroid is found in the Lis thesis paper cited above. This being said we must ALWAYS trust our own bodies when our personal results dont match up with the research no matter how august and respected the medical journals or how many studies have been published showing something that our own unique body is not agreeing with! They affect the skin, liver and immune system precisely the organ systems where these ADRs caused by ranelic acid occur. Any information which you possess would be very much appreciated. Do you take a multivitamin as well? Your bones do need calcium! PMID: 278570 http://dx.doi.org/10.1016/0003-9969(78)90025-0, Li, Zhaoyang. Re strontium yes, the ratio you want is approximately twice as much calcium as strontium. However, I did find one paper, a rat study published in 1963, that considered competition between strontium and magnesium as well as calcium, and results suggest that competition does occur: Epub 2011 Oct 21.) If you are not allergic to dairy foods, then I expect you are likely getting at least several hundred milligrams of calcium from milk, cheese, yogurt, kefir, etc. Youre leading the way for people who will be effected by Osteoporosis. Cortical bone also accumulates far more slowly. I take about 350 mg of magnesium, and 3 tablets of ALTA silica a day, and Vit D3 is 3000, Omega 3 oil. Diffuse hair loss associated with hyperprolactinaemia: report of three cases. You need both trace minerals to produce and utilize thyroid hormones. However, osteomalacia is also frequently seen in end-stage kidney failure patients who are not yet on dialysis and who have normal bone strontium levels. You have been so nice, I actually feel kind of bad for giving you a headache over the above contested quotation from Lis thesis paper. I have also discussed many things that contribute to bone loss that you may not be aware of, and which you can avoid once you know about them. https://www.nejm.org/doi/full/10.1056/NEJMoa1408913, And the incidence of C. difficile infection has been increasing every year. However, make sure you are aware of things like Strontium citrate side effects, as an []. Also, Is it OK to take the strontium with a banana? Hope this helps, Lara, Hi Lara, Joe took a look to see who is in Arizona near Phoenix, and discovered that one of the contributors to the Textbook of Natural Medicine, Dr. Tom Kruzell, ND, is in Scottsdale! I have your excellent book so I will not ask you to repeat anything from there. If you are concerned about this, have either the MVL test or the DUTCH test run to check how your estrogens are being metabolized. 2002-2023 AlgaeCal. 109118,2006. The reasons for this are that failing kidneys lose their ability to: It is so helpful to have technical matters explained with such authority in understandable terms. That makes sense about the calcium dosage. This is how much calcium YOU need to get from supplements. I am genuinely appy to glance at this website posts hich consists f lots of usefl data, tanks for providing tese data. Strontium does indeed increase our absorption of calcium, which increases our need for magnesium (important for muscle and nerve function). Epub 2010 Mar 16. Review. Hi Carol, Curr Osteoporos Rep. 2006 Mar;4(1):34-9. doi: 10.1007/s11914-006-0013-6. Has science and/or the medical field determined whether or not there is a level of strontium not to exceed in the human body? I have asked questions on a number of different blogs or emails to companies and it seems like my posts/emails usually get rejected/or no response, probably because I asked questions that couldnt be accurately answered and thus demonstrated the fallaciousness of the product/marketing claims. .8 in reference to the bone density drop, but sure you figured that out. I am Interested in taking this strontium first thing in the morning so I dont have to think about what Im eating before bed. I am currently taking AlgaeCal and Strontium Boost daily, for 2 years now. Strontium, like calcium, incorporates into both trabecular and cortical bone, but strontium deposits almost entirely into new trabecular bone, with one strontium ion substituting for less than one calcium ion out of 10. The supervised exercise sessions were undertaken as group activities. old and going through menopause, I did research that showed estrogen increases bone mass. You should take Fosamax when your stomach is empty, first thing in the morning. (Is the sentence you quoted somewhere in the full paper? ( I hope you are eating lots of these vegetables like spinach, kale, Swiss chard, broccoli because they contain not only calcium but other minerals and vitamins essential for building healthy bones (e.g., vitamin K1, magnesium, boron). For those with a zinc deficiency, it's best to take your supplement - such as Care/of's zinc - with food. A special form of strontium called strontium ranelate can increase bone formation and prevent bone loss when used in postmenopausal women with osteoporosis. Please feel free to contact our Bone Health Consultants 7 days a week at 1-800-820-0184 (USA & Canada, toll-free) or email [emailprotected] for more information and personalized support! I will look into the Algaecal when my stock of Ca/Mg supps gets down to reorder level. However, even adding 1 Strontium at bedtime causes the loose bowels and squeezing discomfort to return. Our correspondence has been a total delight for me. I am on your bone building plan from your book and taking Algae Cal and Strontium. First of all, 750 mg/d is an excessively high dose higher than that used in all the research Ive seen on strontium. Your thoughts would be much appreciated. Strontium is a chemical element that naturally found in our body in small amounts. For my MK-7 needs, I use AlgaeCals AlgaeCal Plus it provides me with not only K2 (as MK-7) at a dose of 100 mcg an amount shown in the research to be effective but a highly bioavailable and effective form of calcium, also magnesium, boron, and a whole mix of trace minerals all of which play a role in bone health. Strontium can be taken with or without food. This is why you want to be sure to be consuming twice as much calcium (from diet and supplements combined) as strontium. Epub 2012 May 17. Improved healing response in delayed unions of the tibia with low-intensity pulsed ultrasound: results of a randomized sham-controlled trial. Strontium carbonate notably is found in cathode ray tubes in old television sets. Strontiums effect of increasing OPG production was a key factor in the following bone-protective outcomes: greater trabecular bone volume, an increase in the number of trabecular bone cells, larger areas of the bone surface occupied by osteoid cells (osteoid is the last step before final mineralization occurs to produce fully developed new bone tissue), [all trabecular bone] an increase in bone formation rate, and fewer, smaller areas of bone in which osteoclasts were active. When blood pH begins to drop too low (down to 7.35 from a baseline of 7.4), calcium is immediately withdrawn from our bones to restore proper pH in our blood because proper pH is essential for numerous critical life functions, including processes as varied as breathing rate and the ability to transport oxygen throughout our bodies via red blood cells. Be well, Lara. Strontium and calcium share a common carrier system in the intestinal wall, which will. The reason for this is that strontium is very slow to be absorbed by the body. However he asked me to stop taking the Calcium supplement (Caltrate 600D) I thought I heard it wrong but he was quiet sure I dont take any calcium supplement. Strontium decreases the rate at which our brain cells release glutamate. Hey Tyler, He asked me to take for 6 months this Strontium Renalate suspension every year. If you are taking an aromatase inhibitor, you can safely take Strontium Boost alongside this type of medication. Heartburn, stomach pain, or diarrhea; back, muscle, or joint pain; a headache, and flu-like symptoms are the most common side effects. Strontium citrate is not a medication and we dont anticipate that it would have contributed to the development of lymphocytic colitis. I have plaque in my carotid arteries, 20-40% range, I started getting the MK7 with the Algae-Cal, but was already taking some MK-4 drops (5-8 a day). BMD is being used as a marker of estrogen exposure because estrogen plays numerous roles in the maintenance of healthy bones. Mitigation of bone loss with ultrasound induced dynamic mechanical signals in an OVX induced rat model of osteopenia. Also you should know that much of what I have written about strontium ranelate is not provided by AlgaeCal and does not appear on AlgaeCals website or the AlgaeCal Community as our focus is on how to support bone health, not the adverse effects of the bone drugs. I went with my BMD report to a bone doctor which prescribed me with Strontium Renalate suspension. If you feel nauseous, you can take it with a small snack, but if you can wait until an hour after taking it to eat, that's best. That's because your body only takes in what it needs and the rest is excreted through urine. I do plan on continuing the algae cal plus but question if I need 4 capsules each day or if I can cut the dosage. Ive seen the independent lab analysis. My guess is related to the research I am now seeing indicating how important a variety of trace minerals are to healthy bone remodeling and these trace minerals are supplied naturally in AlgaeCal. My primary care physician started prescribing me the 1mg estradiol, and I also take in addition the AlgaeCal & Strontium Boost. Pors Nielsen S. The biological role of strontium. Heres a quote from a paper discussing the differences among readings from different DXA machines: The theoretical values of the strontium ratio were 11.0 for the Hologic Discovery, 9.9 for the GE-Lunar Prodigy, 9.1 for the Demetech Calscan, and 8.5 for the Osteometer Dexacare G4. I am 57-years-old. In addition, the expressions of metabolizing enzymes (CYP3A4/CYP3A9 and UDPG) showed 12 to 193-fold difference between human and rat intestine with distinct regional dependent expression patterns. 2014 Oct 7;4(10):e005787. Now am much better, but lost 8 pts in my hips in that two year period and had a -2.5 in hip this last time. Do you have any suggestions? Hi Anne, what you are doing sounds great. Hi Lara: Heres a quote from one of the more comprehensive papers looking into data from the trials using S. ranelate: after 2 or 3 yr of treatment, the amount of strontium accumulated in bone is sufficient to cause a clinically significant overestimation of BMD of 10% or more. 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